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Efficient synthesis routes for various phthalimido phosphor esters as antimicrobial agents in terms of structure-activity relationship
Journal article   Peer reviewed

Efficient synthesis routes for various phthalimido phosphor esters as antimicrobial agents in terms of structure-activity relationship

Wafaa Mahmoud Abdou and Rizk E. Khidre
Monatshefte für Chemie, Vol.141(2), pp.219-228
01/02/2010
DOI: https://doi.org/10.1007/s00706-009-0244-1

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
A series of phthalimido phosphor derivatives-alpha-amino-phosphonates, amidophosphonates, phosphonic acid diamides, and oxadiazaphospholes-were prepared by applying different types of phosphorus(III) reagents to 2-methoxy-1H-isoindole-1,3(2H)-dione and 2-anilino-1H-isoindole-1,3(2H)-dione. On the basis of bioassay results, some of the new phosphoryl imides could be considered as lead molecules to be modified in order to improve their antibiotic activity.

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