Efflux Pumps, OprD Porin, AmpC beta-Lactamase, and Multiresistance in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients

Maria Tomas; Michel Doumith; Marina Warner; Jane F. Turton; Alejandro Beceiro; German Bou; David M. Livermore; Neil Woodford

doi:10.1128/AAC.00816-09

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Efflux Pumps, OprD Porin, AmpC beta-Lactamase, and Multiresistance in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients

Journal article

Peer reviewed

Efflux Pumps, OprD Porin, AmpC beta-Lactamase, and Multiresistance in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients

Maria Tomas, Michel Doumith, Marina Warner, Jane F. Turton, Alejandro Beceiro, German Bou, David M. Livermore and Neil Woodford

Antimicrobial agents and chemotherapy, Vol.54(5), pp.2219-2224

01/05/2010

DOI: https://doi.org/10.1128/AAC.00816-09

PMCID: PMC2863613

PMID: 20194693

Abstract

Life Sciences & Biomedicine

Microbiology

Pharmacology & Pharmacy

Science & Technology

Expression of ampC, oprD, mexA, mexC, mexE, and mexX was studied in 25 Pseudomonas aeruginosa isolates from cystic fibrosis patients, including 14 isolates of the Liverpool epidemic strain. Overexpressed mexA or ampC and reduced oprD were associated with beta-lactam resistance. A specific combination of mexR, nalC, and nalD mutations occurred in 11 Liverpool strain isolates, including 7 with upregulated mexA.

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Title: Efflux Pumps, OprD Porin, AmpC beta-Lactamase, and Multiresistance in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients
Creators - without role: Maria Tomas - Complejo Hosp Univ A Coruno INIBIC, Microbiol Serv, Unidad Invest, La Coruna, Spain
Michel Doumith - Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
Marina Warner - Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
Jane F. Turton - Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
Alejandro Beceiro - Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
German Bou - Complexo Hospitalario Universitario A Coruña
David M. Livermore - Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
Neil Woodford - Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
Publication Details: Antimicrobial agents and chemotherapy, Vol.54(5), pp.2219-2224
Publisher: Amer Soc Microbiology
Number of pages: 6
Grant note: Spanish Society of Infections Diseases and Clinical Microbiology Program Rio Hortega (CH Universitario A Coruna and ISCIII) REIPI RD06/0008 / Spanish Network for Research in Infectious Diseases
Identifiers: 9921617708331
Academic Unit: King Abdulaziz University; King Saud Bin Abdulaziz University for Health Sciences
Language: English
Resource Type: Journal article