Abstract
A simple, precise, inexpensive and sensitive voltammetnc method has been developed for the determination of gemifloxacm mesylate (GEM) m the presence of tween 80 m the bulk, farmaceutical dosage forms and human unne at gold nanoparticles modified carbon paste electrode (GNCPE) The electrochemical behavior of GEM has been investigated by using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques The electrochemical oxidation of GEM was an irreversible process which exhibited adsorption-diffusion controlled process behavior m Bntton-Robmson (BR) buffer over the entire pH range of values from 2 to 9 The adsorptive stopping response was evaluated as a function of some variables such as pH, type of surfactant, scan rate and accumulation time The anodic peak current varied linearly over the range from 8.0 x 10(-7) to 2.8 x 10(-5) M. The limits of detection and quantification were 7.32 x 10(-8) M and 2.44 x 10(-7) M, respectively The relative standard deviations and the percentage recoveries were found m the following ranges 0.58-1.35% and 99.37-101.76%, respectively.