Abstract
A new europium-acridine-9-carboxylate (Eu(III)-(9-ACA)(2)(NO3)) was synthesized and characterized. The interaction of calf thymus DNA (ct-DNA) with Eu(III)-(9-ACA)(2)(NO3) has been investigated using UV-visible and fluorescence spectroscopic and electrochemical techniques including cyclic voltammetry and differential pulse voltammetry (DPV) on the GCE. UV-absorption spectroscopic techniques were employed to investigate the interaction between the Eu(III)-(9-ACA)(2)(NO3) and ct-DNA. Based on electrochemical and spectroscopic data, the mode of binding of Eu(III)-(9ACA)(2)(NO3) to DNA through intercalation interaction was concluded. The stoichiometric coefficient (n) and apparent binding constant (beta) were calculated to be 1.4 and 9.1 x 10(4) M-1, respectively. The antibtumor activity of the complex against MDA-MB-231 (mammary cancer) and PC-3 (prostate carcinoma) cell lines was evaluated and the results showed promising activities.