Abstract
The enduring period has witnessed various advancements for diverse highlights, such as, speed, selectivity, and decreased expense of electrochemical sensors, especially in the field of pharmaceutical research. Novel materials such as mixed oxide-based nanocomposites always fascinate researchers for their extraordinary properties. Here, based on the use of nanocomposite consisting of ZrO2 and BiVO4 (ZBV) nanoparticles, an electrochemical sensor has been created. The nanocomposite modified glassy carbon electrode (GCE) was used for voltammetric detection of a gastro-prokinetic agent Itopride (ITP). The nanocomposite was characterized for its morphological, structural, and compositional features via XRD, FESEM, EDAX, HRTEM, FTIR and XPS techniques. ZBV/GCE strongly promoted the oxidation current of ITP, as indicated in cyclic and square wave voltammograms. The electrocatalytic process was governed by an adsorption-controlled phenomenon involving one electron and one proton during an oxidation reaction. The oxidation current, best operated at working voltage 0.93 V (vs. Ag/AgCl), increased linearly in the concentration range of 100-1400 nM. The modified GCE exhibited a low detection limit (39.35 nM), good reproducibility (1.81% RSD) and selectivity in presence of other interferents. The application of the developed sensor was scrutinized in pharmaceutical formulation and the biological sample (human blood serum) with satisfactory recoveries.
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