Abstract
The current examination was intended to observe the defensive impacts of embelin against paraquat-incited lung damage in relationship with its antioxidant and anti-inflammatory action. Oxidative stress marker, like malondialdehyde (MDA), antioxidative enzymes, for example, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH Px), inflammatory cytokines, such as interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha, and IL-6, histological examination, and nuclear factor kappa B/mitogen-activated protein kinase (NF-kappa B/MAPK) gene expression were evaluated in lung tissue. Embelin treatment significantly decreased MDA and increased SOD, CAT, and GSH Px. Embelin significantly reduced levels of inflammatory cytokines in paraquat-administered and paraquat-intoxicated rats. In addition, embelin suggestively decreased relative protein expression of nuclear NF-kappa B p65, p-NF-kappa Bp65, p38 MAPK, and p-p38 MAPKs in paraquat-intoxicated rats. The outcomes show the impact of embelin inhibitory action on NF-kappa B and MAPK and inflammatory cytokines release, and the decrease of lung tissue damage caused by paraquat.