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Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives
Journal article   Open access  Peer reviewed

Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives

Hanadi Y. Medrasi, Mariam Abdullah Al-Sheikh and Abdellatif Mohamed Salaheldin
Molecules (Basel, Switzerland), Vol.18(1), pp.535-544
02/01/2013
DOI: https://doi.org/10.3390/molecules18010535
PMCID: PMC6270486
PMID: 23282539

Abstract

4-aminopyrazole enaminonitriles microwave irradiation Thorpe-Ziegler cyclization
Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using the Thorpe-Ziegler cyclization.
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https://doi.org/10.3390/molecules18010535View
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