Abstract
The phase-transfer-catalyzed asymmetric alkylation reactions of N-arylhydrazones derived from -keto-esters and isatin derivatives afford enantioenriched azo compounds that bear a tetra-substituted carbon stereocenter in good yields with high chemo- and enantioselectivity. The alkylation products can be readily converted into chiral amino esters, hydrazine derivatives, and aza--lactams without loss of enantiopurity.