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Enantioselective organocatalytic conjugate addition of amines to alpha,beta-unsaturated aldehydes: one-pot asymmetric synthesis of beta-amino acids and 1,3-diamines
Journal article   Peer reviewed

Enantioselective organocatalytic conjugate addition of amines to alpha,beta-unsaturated aldehydes: one-pot asymmetric synthesis of beta-amino acids and 1,3-diamines

Jan Vesely, Ismail Ibrahem, Ramon Rios, Gui-Ling Zhao, Yongmei Xu and Armando Cordova
Tetrahedron letters, Vol.48(12), pp.2193-2198
19/03/2007
DOI: https://doi.org/10.1016/j.tetlet.2007.01.093

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Organocatalytic asymmetric amine conjugate additions to alpha, beta-unsaturated aldehydes catalyzed by protected diarylprolinols are presented. The reactions proceed with high enantioselectivity and result in Cbz or Boc protected beta-amino aldehydes, gamma-amino alcohols, beta-amino acids and 1,3-diamines with typically 82-99% ee. (c) 2007 Elsevier Ltd. All rights reserved.

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