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Enantioselective synthesis of (R)- and (S)-curcumene and curcuphenol: an efficient chemoenzymatic route
Journal article   Peer reviewed

Enantioselective synthesis of (R)- and (S)-curcumene and curcuphenol: an efficient chemoenzymatic route

Ahmed Kamal, M. Shaheer Malik, Ahmad Ali Shaik and Shaik Azeeza
Tetrahedron: asymmetry, Vol.18(21), pp.2547-2553
22/10/2007
DOI: https://doi.org/10.1016/j.tetasy.2007.10.019

Abstract

Chemistry Chemistry, Inorganic & Nuclear Chemistry, Organic Chemistry, Physical Physical Sciences Science & Technology
An efficient enantioselective synthesis of curcumene and curcuphenol is described. The key intermediates, substituted butanoates 7a and 7b and their acids 8a and 8b are obtained in high enantiopurity (>99% eel by a lipase-catalyzed kinetic resolution process. The enantiopure intermediates thus obtained were utilized for the total synthesis of the target compounds. (c) 2007 Elsevier Ltd. All rights reserved.

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