Abstract
Reconstituted Lyophilized Dry Emulsion Tablets (RLDETs) containing the methanolic extract of the fruit pulp of Adansonia digitata L. (Malvaceae) were prepared using edible oils. The prepared tablets were characterized for disintegration time and droplet size after reconstitution. The tablets were then examined for their hepatoprotective activity against paracetamol-induced hepatotoxicity in rats. Treatment of rats with the lyophilized formulations prior to administration of paracetamol caused a significant reduction of the disturbance in liver function. Liver functions were evaluated by ALT, AST, ALP, total bilirubin and total protein measurements. Antioxidant markers and oxidative stress parameters were also evaluated. The histopathological examination of liver tissue of control and treated animals confirmed the enhanced hepatoprotective activity of the prepared RLDETs.