Abstract
Supercritical fluid extraction (SFE) using carbon dioxide (CO
2
) and liquid CO
2
using Soxhlet (CO
2
-Soxhlet) extraction were employed to extract three (3) antidiabetic compounds viz. stigmasterol, quercetin, and avicularin from Mimosa pudica. Various extraction parameters were studied. Extracts were analyzed pharmacologically, qualitatively and quantitatively to ascertain enrichment levels. All three antidiabetic compounds were effectively enriched under optimized conditions of temperature 60°C, pressure 40 MPa, co-solvent ratio 30%, and CO
2
flow rate of 5 ml min
−1
. SFE was found to be the better method for enrichment of the antidiabetic compounds than the CO
2
-Soxhlet method. Extraction conditions were seen to affect the enrichment of desired compounds.