Abstract
Iron (Fe) deficiency is the most common nutritional problem among children and lead (Pb) toxicity is the most common environmental health threat to children all over the world. The objective of this study was to determine blood lead (BPb) levels and prevalence of Fe deficient anemia among 1 to 5 year old children attending day care clinic in pediatric ward of civil hospital Karachi, Pakistan. A total of 340 children of both genders participating in this study, were screened for anemia. Among them 215 were anemic and 125 non-anemic. The anemic group was further divided in two groups on the basis of % hemoglobin (Hb), mild (Hb <10 g/dL) and severe anemic group (Hb <8 g/dL), while non-anemic as referent children (Hb >10 g/dL). The blood samples were analysed for Pb and Fe, along with hematological parameters. The result indicated that anemic children had a higher mean values of Pb in blood than referent children with Hb >10 g/dL. The Pb levels <100 mu g/L were detected in 40% referent children while 60% of them had >10 mu g/dL. The BPb concentration in severe anemic children (53%) was found in the range of 100-200 mu g/L, whereas 47% had >200 mu g/L. The significant negative correlations of BPb level with % Hb (r= -0.514 and r= -0.685) and Fe contents (r= -0.522, r= -0.762, p<0.001) were observed in mild and severe anemic children respectively. While positive correlation was observed between BPb and age of both group and genders (r= 0.69, p <0.01). The BPb levels were significantly associated with biochemical indices in the blood which have the potential to be used as biomarkers of Pb intoxication and Fe deficient anemia. (C) 2010 Elsevier B.V. All rights reserved.