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Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging
Journal article   Peer reviewed

Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Y. Fatieiev, J. G. Croissant, K. Julfakyan, L. Deng, D. H. Anjum, A. Gurinov and N. M. Khashab
Nanoscale, Vol.7(37), pp.15046-15050
07/10/2015
DOI: https://doi.org/10.1039/c5nr03065j
PMID: 26165456

Abstract

Chemistry Chemistry, Multidisciplinary Materials Science Materials Science, Multidisciplinary Nanoscience & Nanotechnology Physical Sciences Physics Physics, Applied Science & Technology Science & Technology - Other Topics Technology
We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

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