Abstract
The [Pd(AEP)Cl-2] complex was synthesized and characterized, where AEP = 2-(2-aminoethyl)pyridine. The stoichiometry and stability constants of the complexes formed between various biologically relevant ligands (amino acids, peptides, DNA constituents and dicarboxylic acids) and [Pd(A-EP)(H2O)(2)](2+) were investigated at 25 degrees C and 0.1 M ionic strength. The equilibrium constants for the substitution of representative coordinated ligands such as mosine, glycine or methionine by cysteine were calculated and the concentration distribution diagrams of the various species evaluated. The kinetics of base hydrolysis of free and coordinated amino acid esters was investigated. The effects of the medium dielectric constant and temperature on the kinetics of base hydrolysis of the glycine methyl ester in the presence of the [Pd(AEP)(H2O)(2)](2+) complex were studied and the activation parameters Delta H not equal and Delta S not equal for the hydrolysis process were determined. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)