Abstract
The present study was carried out to determine the normative value of the optic disc size, interocular and gender differences and correlate disc size to glaucoma patients measured with Cirrus HD-OCT (Carl Zeiss Meditec, Inc., Dublin, California) device in Saudi population. Retrospective cross-sectional study which included 416 subjects was done. Optic nerve head imaging was obtained by Cirrus HD-OCT (Carl Zeiss Meditec, Inc., Dublin, California) using optic disc scans. Cirrus HD-OCT with the optic disc cube 200x200 protocol was implemented for all subjects, which was divided into 3 groups: normal, glaucoma suspects and glaucoma patients and comparison between groups was carried out using ANOVA test. The mean age of subjects included in the study was 54.9 years +/- 15.38 with 47.8% males and 52.2 % females. Comparison of the interocular difference in disc area in the same subject was found to be slightly larger in the right eye than the left eye (1.98 mm and 1.97 respectively) (ns). Disc area in females was significantly larger than males (p-value= 0.042). Glaucoma suspect patients had larger disc area with an average of 2.19 mm2 in comparison to normal and glaucoma patients (p-value= 0.004). Cirrus HD-OCT is essential for optic disc analysis and quantitative assessment of the ONH. The observed differences in ONH measurements between females and males, glaucoma suspect, and other groups needs further longitudinal studies to evaluate its clinical importance and glaucoma associated risk. In addition, further studies comparing disc size in different regions of Saudi Arabia are recommended.