Evaluation of SLC2A10 ( GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns

Karen L. Mohlke; Andrew D. Skol; Laura J. Scott; Timo T. Valle; Richard N. Bergman; Jaakko Tuomilehto; Michael Boehnke; Francis S. Collins; for the FUSION Study Group; J. Tuomilehto

doi:10.1016/j.ymgme.2005.04.011

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Evaluation of SLC2A10 ( GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns

Journal article

Peer reviewed

Evaluation of SLC2A10 ( GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns

Karen L. Mohlke, Andrew D. Skol, Laura J. Scott, Timo T. Valle, Richard N. Bergman, Jaakko Tuomilehto, Michael Boehnke, Francis S. Collins, for the FUSION Study Group and J. Tuomilehto

Molecular genetics and metabolism, Vol.85(4), pp.323-327

01/08/2005

DOI: https://doi.org/10.1016/j.ymgme.2005.04.011

PMID: 15936967

Abstract

20q

Association analysis

Finnish

GLUT10

Single nucleotide polymorphism

SLC2A10

Type 2 diabetes

The SLC2A10 gene encodes a glucose transporter and is located on chromosome 20q13, where evidence has been found for linkage to type 2 diabetes (T2D) in multiple studies. We investigated SLC2A10 as a T2D candidate gene in Finns. We did not confirm the previously reported association between Ala206Thr and fasting insulin and we observed no statistically significant evidence for T2D association with any single marker. We tested haplotypes for association with diabetes-related traits and observed no excess of significant results.

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Title: Evaluation of SLC2A10 ( GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns
Creators - without role: Karen L. Mohlke - National Human Genome Research Institute
Andrew D. Skol - University of Michigan–Ann Arbor
Laura J. Scott - University of Michigan–Ann Arbor
Timo T. Valle - Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, and Department of Biochemistry, National Public Health Institute, Helsinki, Finland
Richard N. Bergman - University of Southern California
Jaakko Tuomilehto - University of Helsinki
Michael Boehnke - University of Michigan–Ann Arbor
Francis S. Collins - National Human Genome Research Institute
for the FUSION Study Group
J. Tuomilehto - King Abdulaziz University
Publication Details: Molecular genetics and metabolism, Vol.85(4), pp.323-327
Publisher: Elsevier Inc
Identifiers: 9936335908331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article