Abstract
The emergence of multidrug resistance (MDR) among pathogenic bacterial communities poses a serious threat to human and animal medical systems. Thus, the objectives of this research were to compare the phytochemical profiles of the various solvent leaves extracts of Evolvulus alsinoides and Mucuna pruriens. Additionally, evaluate their antibacterial activity against pre-identified MDR bacterial strains such as Pseudomonas aeruginosa 1, P. aeruginosa 2, P. aeruginosa 3, P. aeruginosa 4, Staphylococcus aureus, and Klebsiella pneumoniae. Interestingly, both plant species' methanol extracts contain a significant amount of pharmacologically valuable phytochemicals (commonly contains alkaloids, flavonoids, and tannin), followed by ethanol and benzene extracts. The combined crude methanol extract of these two plants demonstrated significant antibacterial activity against test MDR bacterial strains and was partially comparable to the standard. The methanol leaves extracts of E. alsinoides and M. pruriens contained 11 and 6 major bioactive components, respectively, according to the gas chromatography-mass spectrometry (GC-MS) analysis. The methanol extracts of these plants contained important bioactive components such as propanoic acid, butanoic acid, and palmitic acid. Most of them have been identified as having the potential to be used in biomedical applications. The bioactive components present in the methanol extract of these plants may be sufficient to perform further purification and in-vivo studies.