Abstract
Recent studies indicated that glucose effectiveness (SG) is overestimated and insulin sensitivity (SI) is underestimated with the one-compartment minimal model (1CMM) of glucose kinetics. To correct these errors, Cobelli et al (1999), incorporated a priori knowledge on glucose exchange kinetics using the individual Bayesian estimation to derive SI and SG with the 2CMM during standard IVGTT in healthy subjects. The present study evaluated 2CMM in subjects with type 2 diabetes during insulin-modified IVGTT and compared its performance with 1CMM, and with the glucose clamp as the gold reference. The 2CMM measured the same SI and SG as the 1CMM and underestimated SI measured by the clamp. For its simplicity and popularity and to benefit from the data available in the literature 1CMM is preferred to 2CMM in type 2 diabetes.