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Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Journal article   Peer reviewed

Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Youn-Hi Woo, Roberta P M Fernandes and Philip J Proteau
Bioorganic & medicinal chemistry, Vol.14(7), pp.2375-2385
01/04/2006
DOI: https://doi.org/10.1016/j.bmc.2005.11.012
PMID: 16310360

Abstract

Aldose-Ketose Isomerases - antagonists & inhibitors Fosfomycin - analogs & derivatives Fosfomycin - chemical synthesis Fosfomycin - chemistry Fosfomycin - pharmacology Molecular Structure Multienzyme Complexes - antagonists & inhibitors Oxidoreductases - antagonists & inhibitors Structure-Activity Relationship Synechocystis - classification Synechocystis - drug effects Synechocystis - enzymology
Analogs of the antibiotic fosmidomycin, an inhibitor of the methylerythritol phosphate pathway to isoprenoids, were synthesized and evaluated against the recombinant Synechocystis sp. PCC6803 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR). Fosfoxacin, the phosphate analog of fosmidomycin, and its acetyl congener were found to be more potent inhibitors of DXR than fosmidomycin.

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