Abstract
The present work studied the effect of Moringa oleifera on liver injury induced by the tramal in albino mice. Animals were divided into 4 groups. Group I: control, group II: given Moringa oleifera only (20 mg/kg b.w) for two weeks, group III: given tramal (3 mg/kg) only for two weeks and group IV: given tramal and Moringa oleifera for two weeks. Histopathological liver of tramal -treated mice showed many alterations of lymphocytic aggregation and congested in the blood vessels. Degeneration of hepatocytes with karyolitic nuclei and elongated Kuffer cells were also seen. Biochemical results showed that tramal alone, caused significant increase in liver enzyme, Aspartate transaminase (AST), Alanine transaminase (ALT). Treating animals with tramal and Moringa oleifera led to an improvement in the histological structure of the liver together with significant decrease in levels of liver enzymes (AST and ALT). The present results indicated that Moringa oleifera has ameliorative effect against liver damage induced by tramal and this may be mediated by its antioxidant activity.