Abstract
Ethnopharmacological relevance:
The burden of antimicrobial resistance demands a
continued search for new antimicrobial drugs. The synthetic drugs used clinically have serious side
effects. Natural products or compounds derived from natural sources show diversity in structure and
play an essential role in drug discovery and development.
Objective:
Delphinium roylei is an important medicinal herb of Kashmir Himalaya, India. Traditionally
this medicinal plant treats liver infections, skin problems, and chronic lower back pain. The current
study evaluates the antimicrobial potential of various extracts by in -vitro and in -silico studies.
Methods:
Three extracts and 168 bioactive compounds analysed through LC-MS data, with the vast
majority of them having therapeutic applications. D. roylei have been screened for the antimicrobial
activity against bacteria (Escherichai coli, Streptococcus pneumonia, Haemophilus influenzae, Neisseria
mucosa) and fungi (Candida albicans, Candida glabrata, Candida Paropsilosis) species
through molecular docking using autodock Vina, MD simulation and a broth microdilution method
for minimum inhibitory concentration (MIC) evaluation.
Results:
The extracts and the compounds analyzed through the LC-MS technique of Delphinium
roylie showed significant antimicrobial activity.
Conclusion:
Our study established that the leaf extracts of Delphinium roylei exhibit antimicrobial
activity and thus confirm its importance in traditional medicine.