Abstract
Saliva is a bio-fluid considered similar to blood in that it contains various DNAs, RNAs and proteins. Therefore, it is a fluid with diagnostic potential. In recent time, exosomes are emerging as nano-vesicles which enhance intra-cellular communication. Exosomal content, which is dependent on the cell of origin, reflects physiological status of cells. Exosomes have potentials for use as biomarkers for variant diseases, based on their stability and availability in various body fluids. Current studies have proposed the role of exosomes as immuno-modulators in the etiology of auto-immune diseases and cancers. The present study focused on the role of exosomes as biomarkers and their therapeutic potentials in particular diseases related to the oral cavity.