Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication

Luis M Corrochano; Alan Kuo; Marina Marcet-Houben; Silvia Polaino; Asaf Salamov; José M Villalobos-Escobedo; Jane Grimwood; M Isabel Álvarez; Javier Avalos; Diane Bauer; Ernesto P Benito; Isabelle Benoit; Gertraud Burger; Lola P Camino; David Cánovas; Enrique Cerdá-Olmedo; Jan-Fang Cheng; Angel Domínguez; Marek Eliáš; Arturo P Eslava; Fabian Glaser; Gabriel Gutiérrez; Joseph Heitman; Bernard Henrissat; Enrique A Iturriaga; B Franz Lang; José L Lavín; Soo Chan Lee; Wenjun Li; Erika Lindquist; Sergio López-García; Eva M Luque; Ana T Marcos; Joel Martin; Kevin McCluskey; Humberto R Medina; Alejandro Miralles-Durán; Atsushi Miyazaki; Elisa Muñoz-Torres; José A Oguiza; Robin A Ohm; María Olmedo; Margarita Orejas; Lucila Ortiz-Castellanos; Antonio G Pisabarro; Julio Rodríguez-Romero; José Ruiz-Herrera; Rosa Ruiz-Vázquez; Catalina Sanz; Wendy Schackwitz; Mahdi Shahriari; Ekaterina Shelest; Fátima Silva-Franco; Darren Soanes; Khajamohiddin Syed; Víctor G Tagua; Nicholas J Talbot; Michael R Thon; Hope Tice; Ronald P de Vries; Ad Wiebenga; Jagjit S Yadav; Edward L Braun; Scott E Baker; Victoriano Garre; Jeremy Schmutz; Benjamin A Horwitz; Santiago Torres-Martínez; Alexander Idnurm; Alfredo Herrera-Estrella; Toni Gabaldón; Igor V Grigoriev; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

doi:10.1016/j.cub.2016.04.038

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Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication

Journal article

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Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication

Luis M Corrochano, Alan Kuo, Marina Marcet-Houben, Silvia Polaino, Asaf Salamov, José M Villalobos-Escobedo, Jane Grimwood, M Isabel Álvarez, Javier Avalos, Diane Bauer, …

Current biology, Vol.26(12), pp.1577-1584

20/06/2016

DOI: https://doi.org/10.1016/j.cub.2016.04.038

PMCID: PMC5089372

PMID: 27238284

Abstract

Evolution, Molecular

Gene Duplication

Genome, Fungal

Light

Mucor - genetics

Mucor - radiation effects

Multigene Family

Perception

Phycomyces - genetics

Phycomyces - radiation effects

Signal Transduction - genetics

Transcription, Genetic - radiation effects

Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of P. blakesleeanus and M. circinelloides and show that they have been shaped by an extensive genome duplication or, most likely, a whole-genome duplication (WGD), which is rarely observed in fungi [3-6]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of P. blakesleeanus. A phototropic mutant of P. blakesleeanus with a heterozygous mutation in the photoreceptor gene madA demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes.

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Title: Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication
Creators - without role: Luis M Corrochano - Universidad de Sevilla
Alan Kuo - Joint Genome Institute
Marina Marcet-Houben - Pompeu Fabra University
Silvia Polaino - University of Missouri–Kansas City
Asaf Salamov - Joint Genome Institute
José M Villalobos-Escobedo - Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México
Jane Grimwood - HudsonAlpha Institute for Biotechnology
M Isabel Álvarez - GeneTiCA
Javier Avalos - Universidad de Sevilla
Diane Bauer - Joint Genome Institute
Ernesto P Benito - Universidad de Salamanca
Isabelle Benoit - Westerdijk Fungal Biodiversity Institute
Gertraud Burger - Université de Montréal
Lola P Camino - Universidad de Sevilla
David Cánovas - Universidad de Sevilla
Enrique Cerdá-Olmedo - Universidad de Sevilla
Jan-Fang Cheng - Joint Genome Institute
Angel Domínguez - Universidad de Salamanca
Marek Eliáš - University of Ostrava
Arturo P Eslava - Universidad de Salamanca
Fabian Glaser - Technion – Israel Institute of Technology
Gabriel Gutiérrez - Universidad de Sevilla
Joseph Heitman - Duke University
Bernard Henrissat - Aix-Marseille University
Enrique A Iturriaga - Universidad de Salamanca
B Franz Lang - Université de Montréal
José L Lavín - CIC bioGUNE
Soo Chan Lee - Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
Wenjun Li - Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
Erika Lindquist - Joint Genome Institute
Sergio López-García - Universidad de Murcia
Eva M Luque - Universidad de Sevilla
Ana T Marcos - Universidad de Sevilla
Joel Martin - Joint Genome Institute
Kevin McCluskey - Kansas State University
Humberto R Medina - Universidad de Sevilla
Alejandro Miralles-Durán - Universidad de Sevilla
Atsushi Miyazaki - Ishinomaki Senshu University
Elisa Muñoz-Torres - Universidad de Salamanca
José A Oguiza - Universidad Publica de Navarra
Robin A Ohm - Joint Genome Institute
María Olmedo - Universidad de Sevilla
Margarita Orejas - Instituto de Agroquímica y Tecnología de Alimentos
Lucila Ortiz-Castellanos - Instituto Tecnológico Superior de Irapuato
Antonio G Pisabarro - Universidad Publica de Navarra
Julio Rodríguez-Romero - Universidad de Sevilla
José Ruiz-Herrera - Instituto Tecnológico Superior de Irapuato
Rosa Ruiz-Vázquez - Universidad de Murcia
Catalina Sanz - Universidad de Salamanca
Wendy Schackwitz - Joint Genome Institute
Mahdi Shahriari - Universidad de Salamanca
Ekaterina Shelest - Hans Knöll Institute
Fátima Silva-Franco - Universidad de Murcia
Darren Soanes - University of Exeter
Khajamohiddin Syed - University of Cincinnati Medical Center
Víctor G Tagua - Universidad de Sevilla
Nicholas J Talbot - University of Exeter
Michael R Thon - Universidad de Salamanca
Hope Tice - Joint Genome Institute
Ronald P de Vries - Westerdijk Fungal Biodiversity Institute
Ad Wiebenga - Westerdijk Fungal Biodiversity Institute
Jagjit S Yadav - University of Cincinnati Medical Center
Edward L Braun - University of Florida
Scott E Baker - Pacific Northwest National Laboratory
Victoriano Garre - Universidad de Murcia
Jeremy Schmutz - HudsonAlpha Institute for Biotechnology
Benjamin A Horwitz - Technion – Israel Institute of Technology
Santiago Torres-Martínez - Universidad de Murcia
Alexander Idnurm - University of Missouri–Kansas City
Alfredo Herrera-Estrella - Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México
Toni Gabaldón - Centre for Genomic Regulation
Igor V Grigoriev - Joint Genome Institute
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Publication Details: Current biology, Vol.26(12), pp.1577-1584
Grant note: R01 AI050113 / NIAID NIH HHS
Identifiers: 9936624808331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article