Abstract
A new family of coumarin derivatives (
4a–i) containing a chalcone moiety was synthesized by condensation of 3-acetyl-4-difluoro boryloxycoumarin (
2) with aryl and heteroaryl aldehydes with piperidine in chloroform. Resulting compounds were characterized by IR,
13C,
1H NMR and UV visible spectroscopy. Compound 3-((2E)-3-(3,4,5-Trimethoxy-phenyl)prop-2-enoyl)-2(H)-chromen-2-one (
4g) was characterized by single crystal X-ray diffraction. The antioxidant and antibacterial activities of the obtained compounds
4a-i was evaluated. The biological activity found for these compounds is discussed against their structural features, physical and chemical properties.