Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China

Chunwei Xu; Lu Si; Wenxian Wang; Ziming Li; Zhengbo Song; Qian Wang; Aijun Liu; Jinpu Yu; Wenfeng Fang; Wenzhao Zhong; Zhijie Wang; Yongchang Zhang; Jingjing Liu; Shirong Zhang; Xiuyu Cai; Anwen Liu; Wen Li; Ping Zhan; Hongbing Liu; Tangfeng Lv; Liyun Miao; Lingfeng Min; Yu Chen; Jingping Yuan; Feng Wang; Zhansheng Jiang; Gen Lin; Xingxiang Pu; Rongbo Lin; Weifeng Liu; Chuangzhou Rao; Dongqing Lv; Zongyang Yu; Lei Lei; Xiaoyan Li; Chuanhao Tang; Chengzhi Zhou; Junping Zhang; Junli Xue; Hui Guo; Qian Chu; Rui Meng; Jingxun Wu; Rui Zhang; Xiao Hu; Jin Zhou; Zhengfei Zhu; Yongheng Li; Hong Qiu; Fan Xia; Yuanyuan Lu; Xiaofeng Chen; Rui Ge; Enyong Dai; Yu Han; Weiwei Pan; Jiancheng Luo; Hongtao Jia; Xiaowei Dong; Fei Pang; Kai Wang; Liping Wang; Youcai Zhu; Yanru Xie; Xinqin Lin; Jing Cai; Jia Wei; Fen Lan; Huijing Feng; Lin Wang; Yingying Du; Wang Yao; Xuefei Shi; Xiaomin Niu; Dongmei Yuan; Yanwen Yao; Jianhui Huang; Yinbin Zhang; Pingli Sun; Hong Wang; Mingxiang Ye; Dong Wang; Zhaofeng Wang; Bing Wan; Donglai Lv; Qing Wei; Jin Kang; Jiatao Zhang; Chao Zhang; Genhua Yu; Juanjuan Ou; Lin Shi; Zhongwu Li; Zhefeng Liu; Jing Liu; Nong Yang; Lin Wu; Huijuan Wang; Gu Jin; Liu Yang; Guansong Wang; Meiyu Fang; Yong Fang; Yuan Li; Xiaojia Wang; Yiping Zhang; Shenglin Ma; Biyun Wang; Xiaotian Zhang; Yong Song; Yuanzhi Lu

doi:10.1111/1759-7714.14644

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Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China

Journal article

Open access

Peer reviewed

Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China

Chunwei Xu, Lu Si, Wenxian Wang, Ziming Li, Zhengbo Song, Qian Wang, Aijun Liu, Jinpu Yu, Wenfeng Fang, Wenzhao Zhong, …

Thoracic cancer, Vol.13(21), pp.3084-3097

11/2022

DOI: https://doi.org/10.1111/1759-7714.14644

PMID: 36127731

Abstract

Consensus

Gene Fusion

Humans

In Situ Hybridization, Fluorescence

Neoplasms - pathology

Receptor, trkA - genetics

Receptor, trkC - genetics

Gene fusions can drive tumor development for multiple types of cancer. Currently, many drugs targeting gene fusions are being approved for clinical application. At present, tyrosine receptor kinase (TRK) inhibitors targeting neurotrophic tyrosine receptor kinase (NTRK) gene fusions are among the first "tumor agnostic" drugs approved for pan-cancer use. Representative TRK inhibitors, including larotrectinib and entrectinib, have shown high efficacy for many types of cancer. At the same time, several second-generation drugs designed to overcome first-generation drug resistance are undergoing clinical development. Due to the rarity of NTRK gene fusions in common cancer types and technical issues regarding the complexity of fusion patterns, effectively screening patients for TRK inhibitor treatment in routine clinical practice is challenging. Different detection methods including immunohistochemistry, fluorescence in situ hybridization, reverse transcription-polymerase chain reaction, and (DNA and/or RNA-based) next-generation sequencing have pros and cons. As such, recommending suitable tests for individual patients and ensuring the quality of tests is essential. Moreover, at present, there is a lack of systematic review for the clinical efficacy and development status of first- and second-generation TRK inhibitors. To resolve the above issues, our expert group has reached a consensus regarding the diagnosis and treatment of NTRK gene fusion solid tumors, aiming to standardize clinical practice with the goal of benefiting patients with NTRK gene fusions treated with TRK inhibitors.

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Title: Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China
Creators - without role: Chunwei Xu - Chinese Academy of Sciences
Lu Si - Peking University Cancer Hospital
Wenxian Wang - Zhejiang Cancer Hospital
Ziming Li - Shanghai Chest Hospital
Zhengbo Song - Zhejiang Cancer Hospital
Qian Wang - Nanjing University of Chinese Medicine
Aijun Liu - Chinese PLA General Hospital
Jinpu Yu - Tianjin Medical University Cancer Institute and Hospital
Wenfeng Fang - Sun Yat-sen University Cancer Center
Wenzhao Zhong - Guangdong Provincial People's Hospital
Zhijie Wang - Chinese Academy of Medical Sciences & Peking Union Medical College
Yongchang Zhang - Hunan Cancer Hospital
Jingjing Liu - Jilin Province Tumor Hospital
Shirong Zhang - Hangzhou Cancer Hospital
Xiuyu Cai - Sun Yat-sen University Cancer Center
Anwen Liu - Second Affiliated Hospital of Nanchang University
Wen Li - Second Affiliated Hospital of Zhejiang University
Ping Zhan - Nanjing Medical University
Hongbing Liu - Nanjing Medical University
Tangfeng Lv - Nanjing Medical University
Liyun Miao - Nanjing Drum Tower Hospital
Lingfeng Min - Yangzhou University
Yu Chen - Fujian Provincial Cancer Hospital
Jingping Yuan - Renmin Hospital of Wuhan University
Feng Wang - Nanjing Medical University
Zhansheng Jiang - Tianjin Medical University Cancer Institute and Hospital
Gen Lin - Fujian Provincial Cancer Hospital
Xingxiang Pu - Hunan Cancer Hospital
Rongbo Lin - Fujian Provincial Cancer Hospital
Weifeng Liu - Beijing Tian Tan Hospital
Chuangzhou Rao - University of Chinese Academy of Sciences
Dongqing Lv - Wenzhou Medical University
Zongyang Yu - Fujian Medical University
Lei Lei - Zhejiang Cancer Hospital
Xiaoyan Li - Beijing Tian Tan Hospital
Chuanhao Tang - Peking University International Hospital
Chengzhi Zhou - First Affiliated Hospital of Guangzhou Medical University
Junping Zhang - Shanxi Academy of Medical Sciences
Junli Xue - Shanghai East Hospital
Hui Guo - First Affiliated Hospital of Xi'an Jiaotong University
Qian Chu - Huazhong University of Science and Technology
Rui Meng - Union Hospital
Jingxun Wu - First Affiliated Hospital of Xiamen University
Rui Zhang - China Medical University
Xiao Hu - Zhejiang Cancer Hospital
Jin Zhou - Sichuan Cancer Hospital
Zhengfei Zhu - Fudan University Shanghai Cancer Center
Yongheng Li - Peking University Cancer Hospital
Hong Qiu - Huazhong University of Science and Technology
Fan Xia - Fudan University Shanghai Cancer Center
Yuanyuan Lu - National Clinical Research Center for Digestive Diseases
Xiaofeng Chen - Nanjing Medical University
Rui Ge - Huadong Hospital
Enyong Dai - Union Hospital
Yu Han - Third Affiliated Hospital of Harbin Medical University
Weiwei Pan - Jiaxing University
Jiancheng Luo - Aiyi Technology Co., Ltd, Beijing, People's Republic of China
Hongtao Jia - Aiyi Technology Co., Ltd, Beijing, People's Republic of China
Xiaowei Dong - Department of Pathology, Shanghai OrigiMed Co, Ltd, Shanghai, People's Republic of China
Fei Pang - Department of Pathology, Shanghai OrigiMed Co, Ltd, Shanghai, People's Republic of China
Kai Wang - Department of Pathology, Shanghai OrigiMed Co, Ltd, Shanghai, People's Republic of China
Liping Wang - Department of Oncology, Baotou Cancer Hospital, Baotou, People's Republic of China
Youcai Zhu - Jiaxing University
Yanru Xie - Lishui Central Hospital
Xinqin Lin - First Affiliated Hospital of Guangzhou Medical University
Jing Cai - Second Affiliated Hospital of Nanchang University
Jia Wei - Nanjing Drum Tower Hospital
Fen Lan - Second Affiliated Hospital of Zhejiang University
Huijing Feng - Shanxi Academy of Medical Sciences
Lin Wang - Shanxi Academy of Medical Sciences
Yingying Du - First Affiliated Hospital of Anhui Medical University
Wang Yao - The First Affiliated Hospital, Sun Yat-sen University
Xuefei Shi - Huzhou University
Xiaomin Niu - Shanghai Chest Hospital
Dongmei Yuan - Nanjing Medical University
Yanwen Yao - Nanjing Medical University
Jianhui Huang - Department of Oncology, Lishui Municipal Central Hospital, Lishui, People's Republic of China
Yinbin Zhang - Second Affiliated Hospital of Xi'an Jiaotong University
Pingli Sun - Jilin University
Hong Wang - Chinese PLA General Hospital
Mingxiang Ye - Nanjing Medical University
Dong Wang - Nanjing Medical University
Zhaofeng Wang - Nanjing Medical University
Bing Wan - Nanjing Jiangning Hospital
Donglai Lv - Department of Clinical Oncology, The 901 Hospital of Joint Logistics Support Force of People Liberation Army, Hefei, People's Republic of China
Qing Wei - Zhejiang Cancer Hospital
Jin Kang - Guangdong Academy of Medical Sciences
Jiatao Zhang - Guangdong Academy of Medical Sciences
Chao Zhang - Chinese Academy of Medical Sciences & Peking Union Medical College
Genhua Yu - Shanghai Zhabei District Shibei Hospital
Juanjuan Ou - Southwest Hospital
Lin Shi - Fudan University
Zhongwu Li - Peking University Cancer Hospital
Zhefeng Liu - Chinese PLA General Hospital
Jing Liu - Ruijin Hospital
Nong Yang - Hunan Cancer Hospital
Lin Wu - Hunan Cancer Hospital
Huijuan Wang - Henan Cancer Hospital
Gu Jin - Department of Bone and Soft-Tissue Surgery, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, People's Republic of China
Liu Yang - Zhejiang Provincial People's Hospital
Guansong Wang - Army Medical University
Meiyu Fang - Department of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, People's Republic of China
Yong Fang - Zhejiang University
Yuan Li - Fudan University Shanghai Cancer Center
Xiaojia Wang - Department of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, People's Republic of China
Yiping Zhang - Department of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, People's Republic of China
Shenglin Ma - Zhejiang University
Biyun Wang - Fudan University Shanghai Cancer Center
Xiaotian Zhang - Peking University Cancer Hospital
Yong Song - Nanjing University
Yuanzhi Lu - First Affiliated Hospital of Jinan University
Publication Details: Thoracic cancer, Vol.13(21), pp.3084-3097
Identifiers: 9941550208331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article