Abstract
The reaction of the starting compound, 7-acetyl-4- cyano-1,6-dimethyl-8-phenyl-7,8-dihydroisoquinoline-3(2H)-thi-one, with some N-aryl-2-chloroacetamides or chloroacetonitrile, in the presence of sodium acetate trihydrate, gave the corresponding substituted 3-methylsulfanyl-7-acetyl-4-cyano-1,6-dimethyl-8-phe-nyl-7,8-dihydroisoquinolines. Upon heating of the latter com-pounds with sodium methoxide in methanol, they underwent intramolecular Thorpe-Zeigler cyclization, affording the target isomers 1-amino-2-(substituted)-5,8-dimethyl-6-phenyl-6,7-dihydrothieno[2,3-c]isoquinolines (DHTIQs). The chemical struc-tures of all produced substances were characterized by elemental and spectral analyses. The photophysical characteristics of the produced DHTIIQs (He1-Ph-Cl, He2-Ph-CH3, He3-Ph, and He4-CN) have been investigated as luminous compounds. Potentiodynamic, surface morphology, and theoretical calculations were used to study the behavior of the synthesized DHTIQs as corrosion inhibitors on mild steel in a 1.0 M sulfuric acid solution.