Abstract
Background/Aim: Phosphatidyl-inositol-3-kinase (PI3K), a cancer therapeutic target, has been exploited for cancer therapy. The natural compounds flavonoids have increasingly been shown to possess anticancer activity. The current study aimed to explore all known flavonoids for their ability to inhibit PI3K gamma. Materials and Methods: Virtual screening of flavonoids using molecular docking to the ATP binding site of PI3K gamma was performed. The top 10 scoring flavonoids were selected for pose analysis and binding strength scores. Results: Molecular docking revealed that the 10 selected flavonoids might inhibit PI3K gamma kinase activity. Literature search did not identify studies reporting a bioassay activity for any of these compounds. Conclusion: All 10 selected flavonoids are potential PI3K gamma kinase inhibitors and anticancer agents. Interestingly, one of the 10 least scoring flavonoids has been reported to be inactive, as expected, and thus validating the accuracy of the results.