Abstract
The medical records of 24 cats with histopathologically diagnosed feline infectious peritonitis involving the nervous system were reviewed. Seventeen cats had historical, clinical, and pathological findings of systemic disease. Twelve cats had focal signs of central nervous system dysfunction. Twelve cats had multifocal signs including seizures, nystagmus, head tilt, vestibular or cerebellar ataxia, paresis, and proprioceptive loss with a preponderance of caudal fossa signs. Computed tomography of the brain revealed hydrocephalus in two cats. Examination of cerebrospinal fluid revealed pyogranulomatous pleocytosis in five cats; the tap was nonproductive in five cats. Findings on histopathological examination of appropriate tissues included nephritis, hepatitis, and pleuritis. Neuropathological findings included ependymitis, choroid plexitis, meningitis, encephalitis, and myelitis. Hydrocephalus was seen in 18 cats on necropsy.