Abstract
The USP XXII specifies that the disintegration time for nitrofurantoin tablets must he not. less than 30 minutes, not, Less than 25% of the drug is dissolved in 60 minutes and not less than 85% is dissolved in 120 minutes. These specifications were done to minimixe the side effects and to achieve a proper bioavailability for the drug.
On testing the market tablet, preparation (Furadantin), it was found that it does not fit to the USP specifications. Nine nitrofurantoin tablet formulations were then tried and each was studied for disintegration time and % dissolution in the first and second hours. The best formula was found to be consisted of adding 2% of collodion in 40% of the starting granules, coated with 4% CAP and adding another 2% of collodion to the remaining 60% of the granules.