Abstract
A study has been carried out lo examine the effect of storage conditions on the chemical stability of thiamine hydrochloride contained in three batches of multivitamin sugar-coated tablets. The study revealed the instability, of this vitamin under the influence of storage condition. Prediction of instability was accomplished through an Arrhenius plot; the theoretically derived value was in agreement with the experimentally calculated values. A shelf life of 12.5 months was found for a brand with labeled shelf-life of 3 years. Stabilized formulation of thiamine-containing tablets was suggested. A batch of thiamine hydrochloride tablets was prepared by direct compression with environmental pH adjusted to 3.2. A stability testing was carried out at elevated temperatures 50-degrees-C, 60-degrees-C and 70-degrees-C under uncontrolled and controlled relative humidity of 65 % and 92 %. The prepared tablets showed excellent stability under the accelerated condition examined