Abstract
A novel four-component domino reaction for the synthesis of 8-methyl-9- substituted-2,10-diaryl-2,3-dihydro-10H-pyrano[3,2-e][1,2,4,3]triazaphospholo[1,5-c]pyrimidines has been established. The reaction was performed in THE using readily available 5-substituted-2-amino-6-methyl-4-phenyl-4H-pyran-3-carbonitrile, dimethylformamide dimethyl acetal, hydrazine hydrate and aryldichlorophosphine. The simple and efficient one-pot four-component approach, catalyst free and mild reaction conditions made the present methodology a good synthetic procedure.