Abstract
New series of Mg(II), Ca(II), Sr(II) and Ca(II) complexes with indomethacin (indo) anti-inflammatory drug have been synthesized. These complexes have been characterized by different physico-chemical techniques like elemental analysis, FT-IR, UV-Vis spectroscopy, H-1-NMR spectroscopy, conductance measurements, and thermogravimetric analysis. Spectroscopic studies suggest coordination of all complexes in a regular octahedral arrangement in 2L:1M molar ratio by two O-carboxylate group and four coordinated water molecules in the form of [M(L)(2) (H2O)(4)], M metal, L ligand (indo). The FT-IR spectra of complexes indicate the involvement of the -COOH group in the complexation after deprotonation as monodentate. The nanoscale range of the prepared complexes was analyzed based on transmittance electron microscopy (TEM). Complexes have been screened for their antibacterial (Gram negative bacteria (Escherichia coli), (Gram positive bacteria (Bacillus subtilis) and antifungal (Aspergillus niger and Aspergillus flavus) showing promising antimicrobial biological activity.