Abstract
Background: The ABO blood groups are A, B, AB and O. There is a relationship between ABO blood group and different disease. The aim of this study was to detect the frequency of ABO blood group in Saudi Arabia in the Makkah city and to detect their relation to diseases. Methods: This study included 607 subjects, 583 were Saudi, and 24 were non-Saudi. They were 341men and 266 women. All were subjected to multiple questionnaires which include, age, sex, marital status, number of children if married, blood group, history of malaria infection, history of dengue fever infection and history of ABO hemolytic disease of the newborn in mothers of blood group O. Results. 49.5% were blood group O, 28.6% were blood group A, 17.9% were blood group B and 3.8%. were blood group AB. 91.9% being Rh positive and 7.9% were Rh negative. The highest frequency of malaria infection was observed in blood group AB (8.7%) followed by O (2.7%). Whereas, the highest frequency of dengue fever infection was observed in blood group B (10.1%) followed by O (8%). Conclusion: The frequency of blood group in the Makkah city are O followed by A then B and lastly AB. Blood group AB and B are more liable to malaria and dengue fever infection respectively. They are followed by O blood group in both conditions.