Abstract
The bioglasses with composition 40P(2)O(5) -20Na(2) O-10Ca(OH)(2)-20CaCl(2)-8.0ZnO-2.0BaF(2) in mol% (labeled BGBaF) was fabricated by melt quenching technique. The phase of beta tricalcium phosphate (beta-TCP) estimated by using X-ray diffraction (XRD) and scanning electron microscope SEM. We studied the effect of the present bioglass with respect to antimicrobial activity, anti-proliferative/cytotoxicity against normal and activated splenic cells. The results obtained that the BGBaF (powder) and BGBaF (nanoparticles) had antimicrobial activities against Gram negative and positive bacteria as well as fungi. We note that the antimicrobial activity of nanoparticles was more than comparing with powder. Otherwise the BGBaF (powder) demonstrated a cytotoxic effect on normal splenic cells with stronger effect regarding the BGBaF nanoparticles. In addition BGBaF (powder) showed no effects on activated splenic cells. With respect to the results above the present bioglasses can be used in the biomedical application.