Abstract
There have been strong demands for nanofibrous scaffolds fabricated by electrospinning for various fields due to their various advantages. Electrospun poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV) fibre mats were prepared. The effects of processing variables as well as the inclusion of poly(ethylene glycol) (PEG) on the morphologies of generated fibres were investigated using Fourier‐transform infrared spectroscopy and scanning electron microscopy. The average fibrous diameter was monitored in the range 400–3000 nm relying on the total content of PEG. The fluorescence cell imaging of electrospun mats was also explored. The results of cell viability demonstrated that skin fibroblast BJ‐1 cells showed different adhesions and growth rates for the three kinds of PHBV fibres. Electrospun PHBV mats with low amount of PEG offer a high‐quality medium for cell growth. Therefore, those mats exhibited high potential for soft tissue engineering, in particular wound healing.
Electrospun PHBV mats with ordered morphology were prepared. Effects of processing variables and inclusion of PEG were explored. The average fibrous diameter was monitored in the range of 400‐3000 nm. Different adhesions and osteogenic effects were observed on PHBV fibers. Low PEG offers an osteogenic differentiation and good medium for cell growth.