Abstract
In this study we report the fabrication of an electrochemical sensor employing copper waste recycling product and its application for omeprazole determination. The electrode consists of carbon paste electrode (CPE) decorated with CuO-nanoparticles. Cyclic voltammetry (CV) and anodic linear sweep voltammetry (ALSV) techniques were used to explore the competence of the first time reported sensor toward omeprazole under various experimental settings including the supporting electrolyte composition, pH, and scan rate. Comparison of CPE and CuO NPs/CPE electrodes reveals that this modified electrochemical sensor exhibits superior analytical performance of omeprazole. Two oxidation peaks were detected at ∼0.96 V and 1.07 with no corresponding reduction peaks. About ∼15 μA increase of anodic peak current was reported by the modified CPE in comparison to the unmodified one. The analytes concentration (0.1−2.0 μM) was found to vary linearly with the oxidation peak current and a detection limit of 0.013 μM was certified. Moreover, the newly designed electrode exhibited good reproducibility, high stability and selectivity to omeprazole in the presence of some interferences. Hence, it was successfully nominated to determine omeprazole in tablets and serum. The results revealed that the incorporation of CuO nanomaterials into the CPE significantly enhanced its electrochemical reactivity and voltammetric response to omeprazole along with speeding up the charge transfer process on its surface.