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Facile access to a benzoazepinoquinazolinone via a free radical cyclization
Journal article   Peer reviewed

Facile access to a benzoazepinoquinazolinone via a free radical cyclization

Khaled Q. Shawakfeh, Zakariyya N. Ishtaiwi and Naim H. Al-Said
Tetrahedron letters, Vol.55(7), pp.1329-1331
12/02/2014
DOI: https://doi.org/10.1016/j.tetlet.2014.01.013

Abstract

Benzoazepinoquinazolinone Cyclopropanequinone Duocarmycin Free-radical Quinazolinone
An efficient synthetic protocol based on a free-radical cascade reaction via 6-exo-trig and 7-endo-trig cyclization processes is described for a new substituted benzoazepinoquinazolinone system which could in principle be used to form the cyclopropanequinone system found in duocarmycins.

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