Sign in
Back
Facile access to a heterocyclic, sp(3)-rich chemical scaffold via a tandem condensation/intramolecular nitrone-alkene [3+2] cycloaddition strategy
Journal article   Open access  Peer reviewed

Facile access to a heterocyclic, sp(3)-rich chemical scaffold via a tandem condensation/intramolecular nitrone-alkene [3+2] cycloaddition strategy

M. J. Rawling, T. E. Storr, W. A. Bawazir, S. J. Cully, W. Lewis, M. S. I. T. Makki, I. R. Strutt, G. Jones, D. Hamza and R. A. Stockman
Chemical communications (Cambridge, England), Vol.51(64), pp.12867-12870
18/08/2015
DOI: https://doi.org/10.1039/c5cc05070g
PMID: 26169627

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
A heterocyclic, sp(3)-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone-alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced.
url
https://doi.org/10.1039/c5cc05070gView
Published (Version of record) Open

Metrics

1 Record Views

Details