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Facile catalyst-free pseudo five-component domino reactions in the expedient synthesis of 5-aroyl-1,3-diarylhexahydropyrimidines
Journal article   Peer reviewed

Facile catalyst-free pseudo five-component domino reactions in the expedient synthesis of 5-aroyl-1,3-diarylhexahydropyrimidines

Sivasubramanian Muthusaravanan, Subbu Perumal and Abdulrahman I. Almansour
Tetrahedron letters, Vol.53(9), pp.1144-1148
29/02/2012
DOI: https://doi.org/10.1016/j.tetlet.2011.12.097

Abstract

(E)-3-(Dimethylamino)-1-arylprop-2-en-1-one 5-Aroyl-1,3-diarylhexahydropyrimidines Aniline Domino reaction Formaldehyde
The pseudo five-component domino reactions of (E)-3-(dimethylamino)-1-arylprop-2-en-1-one, formaldehyde and aniline afford 5-aroyl-1,3-diarylhexahydropyrimidines in good yields under catalyst-free conditions. This transformation involving 4 C–N and 1 C–C bond formations in a one pot operation presumably proceeds via Michael addition–elimination–Mannich type reaction-condensative annulation–reduction sequence.

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