Abstract
An innovative electrochemical nanoprobe, for analysis of salinomycin (SAL), was proposed. The nanoprobe based on decoration of glassy carbon electrode (GCE) with 3D rose like La3+@ ZrO2 supported on reduced graphene oxide (RGO) nanosheets. The 3D rose like La3+@ ZrO2 was synthesized via sintering process. The successful decoration of 3D rose like La3+@ ZrO2 on the surface of RGO was characterized using different spectroscopic and analytical techniques. The obtained voltammetric results confirmed the good electrochemical performance of 3D rose like La3+@ ZrO2 in terms of lower peak potential (Epc) and higher cathodic current (Ipc). Moreover, the modified nanoprobe showed wide linearity range (0.34–115 × 10−8 M), lower detection limit (0.11 × 10−8 M) and higher selectivity. Besides, the nanocomposite showed good applicability for analysis of SAL in biological fluids and during pharmacokinetic evaluation in rabbit plasma. The obtained results opens a new venue for the determination of futuristic drug, SAL, during pharmacokinetic and pharmacodynamics studies.
•3D like La3+@ZrO2 was prepared by facile hydrothermal co-precipitation method.•Reduced graphene oxide (RGO) was used as supporter and a signal amplifier.•3D like La3+@ZrO2 NFs/RGO is efficient electro-catalyst for salinomycin (SAL).•The proposed sensor exhibited good sensitivity, reproducibility, stability and selectivity towards SAL analysis.•The proposed sensor shows good applicability towards SAL and during pharmacokinetic evaluation.