Abstract
UV–vis spectrum recorded as a function of time of reaction of aqueous solution of chloroauric acid with C. auriculata extract and inset shows the color change during synthesis. Facile synthesis of AuNPs using antidiabetic potent plant resulted in gold nanoparticles of average size 15–25
nm, stable at a wide range of pH [3.4–10.2] which may have the potential to be used in antidiabetic treatment have been synthesized in the study.
[Display omitted]
► In the present work synthesis of gold nanoparticles has been carried out using
Cassia auriculata an antidiabetic potent plant. The main aim of the present investigation is to emphasize that the role of stabilizing and capping molecules may promote the activity of gold nanoparticles in drug delivery applications. The biocompatibility and the less toxic nature of the gold nanoparticles coupled with stabilizing compounds of antidiabetic plant may induce a hypoglycemic effect. ► Characterization techniques such as UV-vis to check the surface plasmon resonance in the reduction of auric chloride, FT-IR to find out the possible biomolecules involved in the stabilization and capping of gold nanoparticles, TEM to elucidate the size and shape, SEM to check the surface morphology, EDAX to find out the elemental composition and XRD for crystalline nature were carried out. ► The average size 15–25 nm and other standard characterizations were also done. The gold nanoparticles were stable at a wide range of pH [3.4–10.2] which can be used for drug delivery applications. Selection of medicinal value plants in synthesis of gold nanoparticles will create a new platform to utilize the potential of herbal medicine in nanoscience for drug delivery and biomedical applications.
A simple biological method for the synthesis of gold nanoparticles (AuNPs) using
Cassia auriculata aqueous leaf extract has been carried out in the present study. The reduction of auric chloride led to the formation of AuNPs within 10
min at room temperature (28
°C), suggesting a higher reaction rate than chemical methods involved in the synthesis. The size, shape and elemental analysis were carried out using X-ray diffraction, TEM, SEM-EDAX, FT-IR and visible absorption spectroscopy. Stable, triangular and spherical crystalline AuNPs with well-defined dimensions of average size of 15–25
nm were synthesized using
C. auriculata. Effect of pH was also studied to check the stability of AuNPs. The main aim of the investigation is to synthesize AuNPs using antidiabetic potent medicinal plant. The stabilizing and reducing molecules of nanoparticles may promote anti-hyperglycemic if tested further.