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Facile synthesis of 3-substituted quinazoline-2,4-dione and 2,3-di-substituted quinazolinone derivatives
Journal article   Peer reviewed

Facile synthesis of 3-substituted quinazoline-2,4-dione and 2,3-di-substituted quinazolinone derivatives

Mahmoud Farouk, Salman Alrokayan, Ahamad Imran, Khalid Abu-Salah, Mohamed Ghazzali, Khalid Al-Farhan, Salem El-Gohary and Mamdouh Adly
Chemical papers, Vol.67(2), pp.229-235
01/02/2013
DOI: https://doi.org/10.2478/s11696-012-0266-8

Abstract

2,3-disubstituted quinazolinones 3-nitrophthalic acid anhydride 3-substitued quinazoline-2,4(1H,3H)-diones N-hydroxy-3-nitrophthalimide N-sulphonyloxy-3-nitrophthalimide
3-Substituted quinazoline-2,4(1H,3H)-dione and 2,3-di-substituted quinazolineone derivatives attract considerable interest due to their pharmacological properties. In this paper, we report the synthesis of N-substituted-3-nitrophthalimide derivatives II–III, the reactions of phthalimide III with amines, hydrazines, and amino acid derivatives to synthesise a small library of 3-substituted-5-nitroquinazoline-2,4(1H,3H)-diones IV–XIV and 2,3-di-substituted-6-nitro-quinazolineones XVIII–XIX.

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