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Factor and rifampicin influencing RNA polymerase isolated from chromatin of eukaryotic cell
Journal article   Peer reviewed

Factor and rifampicin influencing RNA polymerase isolated from chromatin of eukaryotic cell

H. Mondal, R.K. Mandal and B.B. Biswas
Biochemical and biophysical research communications, Vol.40(5), pp.1194-1200
10/09/1970

Abstract

Two RNA-polymerases (I and II) and several protein fractions (A, B and C) have been isolated from chromosomal acidic proteins of coconut nuclei. Fraction B stimulates the activity of both the RNA-polymerases and appears to be an initiation factor. RNA-polymerase I is sensitive to rifampicin when the drug is added to the enzyme first before the addition of factor B, but insensitive when the order of addition is reversed. Fraction C has an inhibitory effect on both the RNA-polymerases.

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