Abstract
Background: Sickle cell disease (SCD) is a common hereditary haematological disorder affecting millions worldwide. The current study aimed to improve the quality of life in SCA patients by Periodic psychological assessment and early detection of psychological effects, optimizing the patient's and family's adaptation to the illness. Methodology: This study was a survey-based crosssectional study conducted in Al-Qunfudah governorate, Saudi Arabia. Sickle Cell Disease Burden Interview (SCDBI) vailed questionnaire was used in interviewing the participants. Results: A total of 107 participants participated in the study. The vast majority of the samples have SCA alone 50.47%, with one child with SCA 46.73%. Conclusion: Early discovery of the psychological effect of SCD is the fundamental goal to achieve to optimize the patient's and family's adaptation to the illness.