Abstract
Polycystic ovarian syndrome is one of the common endocrinopathies of females of reproductive age group. This syndrome is having familial predisposition. The basic problem is in the Hypothalamic pituitary axis leading to increased LH/FSH ratio. Insulin resistance is common finding and resultant hyperinsulinemia leads to altered steroid Hormone metabolism and various manifestations of this syndrome. In this study 60 female patients of PCOS half obese and half non obese were taken from Gynae and obstetric OPD of Services Hospital Lahore. They were diagnosed on the basis of history, clinical Examination and raised LH/FSH ratio. 40 females half obese and half non obese were taken as control. The fasting glucose and insulin levels were determined in both case and controls. The ratio was calculated. When compared it was found that fasting glucose did not differ significantly but insulin levels were significantly higher especially in obese group. So ratio of glucose to insulin (GIR) was decreased. Cut off value was taken 4.5. It was seen that 33% of non obese & 60% of obese cases were having GIR less than 4.5 so they were found to be insulin resistant & require insulin sensitizing drugs.