Abstract
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•Novel and primary model of sulfonamide compounds encompassing a chromene azo motif.•Cytotoxic screening was performed against three cancer cell lines: HCT-116, HepG-2, and MCF-7.•Inhibitory effect analyses against the HDAC classes and the Tubulin polymerization.
This report presents the development of a novel and primary model of sulfonamide compounds encompassing a chromene azo motif with the intent of becoming applicable for drug candidates in the cases of drug-resistant pathogens. The novel molecules (7a–n) have been synthesized via a two-step reaction. First, 4-((2, 4-dihydroxyphenyl)diazenyl)benzenesulfonamide (3a–e) were obtained through the reaction of their corresponding diazotized 4-aminobenzenesulfonamides (1a–e) with resorcinol, followed by the heterocyclization of 3a–e with arylidenemalononitriles (6a–d). Upon structural identification, the newly synthesized compounds were evaluated for their antibacterial and antifungal activities. Moreover, their cytotoxic screening was performed against three cancer cell lines: HCT-116, HepG-2, and MCF-7. Further examinations were comprised of the inhibitory effect analyses of the novel sulfonamide/chromene derivatives against the HDAC classes and the Tubulin polymerization in order to discern the prime antitumor drug candidates.