A short synthesis of 4″-(
S)-4″-deoxy-4″-trifluoroacetylamino-4″-alkylcarbamoyl-avermectin B
1
4 has been developed through the diastereoselective Ugi reaction to an phenylsulfinimide intermediate.
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Title
First example of an Ugi type reaction on phenylsulfinimine-avermectin B 1 derivatives