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Fluorescent labeling of peptides on solid phase
Journal article   Peer reviewed

Fluorescent labeling of peptides on solid phase

Alan R. Katritzky, Megumi Yoshioka, Tamari Narindoshvili, Alfred Chung and Jodie V. Johnson
Organic & biomolecular chemistry, Vol.6(24), pp.4582-4586
01/01/2008
DOI: https://doi.org/10.1039/b811693h
PMID: 19039367

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
N-alpha-Fmoc-N-alpha-[(7-methoxycoumarin-4-yl)acetyl]-L-lysine (N-alpha-Fmoc-L-Lys(Mca)-OH) 3 is conveniently prepared by benzotriazole methodology (52% over two steps). N-Acylbenzotriazoles Mca-Bt 2, N-alpha-Fmoc-L-Lys(Mca)-Bt 4, coumarin-3-ylcarbonyl (Cc)-Bt 5, N-alpha-Fmoc-L-Lys(Cc)-Bt 7 and N-alpha-(Cc)-L-Lys(Fmoc)-Bt 9 enable the efficient microwave enhanced solid-phase fluorescent labeling of peptides.

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