Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature

Nedal Bukhari; Abdulraheem Alshangiti; Emad Tashkandi; Mohammed Algarni; Humaid O. Al-Shamsi; Hamoud Al-Khallaf

doi:10.3390/clinpract11030062

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Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature

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Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature

Nedal Bukhari, Abdulraheem Alshangiti, Emad Tashkandi, Mohammed Algarni, Humaid O. Al-Shamsi and Hamoud Al-Khallaf

Clinics and practice, Vol.11(3), pp.467-471

27/07/2021

DOI: https://doi.org/10.3390/clinpract11030062

PMID: 34449540

Abstract

5-Fluorouuracil

chemotherapy

dihydropyrimidine dehydrogenase

DPYD

polymorphism

Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report cases from our institute with colorectal cancer who experienced severe toxicities to standard dose 5-FU based chemotherapy. DPYD gene sequencing revealed rare different polymorphisms that prompted dose adjustments of administered 5-FU and capecitabine. To our knowledge, this is the first case series looking at DPYD polymorphisms in the Saudi Arabian population.

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Title: Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature
Creators - without role: Nedal Bukhari
Abdulraheem Alshangiti - King Fahad Specialist Hospital
Emad Tashkandi - Umm al-Qura University
Mohammed Algarni - King Abdulaziz Medical City
Humaid O. Al-Shamsi - University of Sharjah
Hamoud Al-Khallaf - King Fahad Specialist Hospital
Publication Details: Clinics and practice, Vol.11(3), pp.467-471
Publisher: MDPI
Identifiers: 9915416308331
Academic Unit: Imam Abdulrahman Bin Faisal University; Umm Al Qura University; King Abdulaziz University
Language: English
Resource Type: Journal article